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The body excretes excess water-soluble B12 in urine
5-amino-1mq successfully inhibits NNMT in cell cultures and animal models
In vitro, 5-Amino-1MQ at 30 M in 3T3-L1 adipocytes significantly reduced intracellular 1-MNA levels, confirming NNMT target engagement
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Selective and membrane-permeable small-molecule inhibitors of NNMT reverse high-fat-diet-induced obesity in mice and remodel adipocyte metabolism (open-access)
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