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When exposed to Ex-4, cell cycle analysis revealed an increase of cells in S (synthesis)-Phase [15, 16] and proliferation related markers ( cyclin D3 , cyclin-dependent kinase 4 ( CDK4 ), c-Myc and c-fos ) increased, while cell cycle inhibitors ( p21Cip1 and p27Kip1 ) were downregulated [16]
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Asthma and respiratory conditions pose particular risks, especially with inhaled forms
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The trade-offs among clinical effectiveness, tolerability, and cost for GLP-1RA use have highlighted the importance of a cost-effectiveness analysis (CEA) of GLP-1RA versus insulin therapy in real-world clinical practice [2]
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