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GLP-1R agonists impact visceral pain, with specific relevance to IBS

To improve the pharmacokinetic profile and further explore the therapeutic potential of such an endogenously based GLP-1R/GcgR co-agonist, a DPP-IV-resistant OXM analogue was developed by adding a d-stereoisomer of serine at position 2 and a cholesterol moiety to the C-terminal domain

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But those facts do not turn a research-use-only vial into a medicine

These expectations can influence persistence and shape how patients respond to challenges during treatment