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Common adverse effects reported with Ozempic include: Gastrointestinal symptoms : nausea, vomiting, diarrhoea, constipation, and abdominal pain (particularly during dose escalation) Injection site reactions : redness, itching, or discomfort at the injection site Hypoglycaemia : especially when used in combination with insulin or sulfonylureas (doses of these medications may need reduction to minimise this risk) [3] [14] More serious but less common risks include: Pancreatitis : patients should be advised to seek immediate medical attention if they experience severe, persistent abdominal pain [22] [23] Gallbladder disease : including cholelithiasis and cholecystitis Diabetic retinopathy complications : particularly in patients with pre-existing retinopathy Acute kidney injury : risk increases with dehydration from severe gastrointestinal side effects Thyroid C-cell tumours : observed in rodent studies, though the relevance to humans remains uncertain [3] [14] Ozempic should not be used during pregnancy and should be discontinued if pregnancy occurs
When patients discontinue GLP-1 receptor agonist medications like semaglutide, research indicates that 50 to 80 percent regain a substantial portion of lost weight within 12 months
Keith Try Ung, PhD Andreas Boeckl Mercedes Meyer Stephen Nava Hunter Gillies MB ChB Blaine Bueche Gary W
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Some individuals report increased energy or mild restlessness, particularly when taking methylcobalamin later in the day, which may affect sleep patterns in sensitive individuals
