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To assess cell viability, CellTiter-Glo (Promega) reagent was added according to the manufacturers instructions, and luminescence was measured using a microplate reader
252,254 In the phase 3 trials, headache was the most common treatment-emergent adverse event
The peptide dissolves readily at pH values achievable with water, and the absence of salts minimizes ionic interactions during initial dissolution
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It also inhibits TGF-beta1, a cytokine that promotes fibrosis
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