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Bio-assay guided isolation of -glucosidase inhibitory constituents from Hibiscus mutabilis leaves

For subjects treated with the highest dose of tirzepatide (15 mg per week), the risk to develop any major adverse cardiovascular event (MACE-4 composed of myocardial infarction, stroke, hospitalization for angina, and all-cause death) was estimated at 050 (026095)

However, wild-type p53 is expressed in normal tissues, resulting in possible toxicity