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This glucose-dependency is central to the safety profile of GLP-1 agonists
112 However, in recent years, the FDA has introduced the patient-focused drug development initiative, where patient-reported outcomes such as improvements in quality of life and healthy life years in MASH patients following treatment can serve as trial endpoints, potentially influencing final approval based on these data
Arvanitakis K, Koufakis T, Popovic D, Maltese G, Mustafa O, Doumas M, Giouleme O, Kotsa K, Germanidis G
The continuous, low-grade viral replication drives a perpetual state of neuro-inflammation, which manifests clinically as the severe brain fog, unrefreshing sleep, and post-exertional malaise (PEM) that define ME/CFS and Long COVID
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