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Clear instructions covering drug information, storage, temperature handling, and injection technique

A plateau at this stage is likely a sign of reaching maximum medication effect rather than a problem to fix

Care was taken to avoid venous sampling, and blood was passively drawn into the syringe under physiological arterial pressure

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Consistent with this finding, pharmacological activation of A 2A R or optogenetic activation of A 2A R-expressing neurons in the dorsomedial striatum (DMS) decreases alcohol-seeking behaviors [70]