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PT-141 (Bremelanotide) activates receptors in the brain related to arousal, desire, and sexual response
Whereas much of the current attention surrounding GLP-1 RAs, or glucagon-like peptide-1 receptor agonists, has been focused on their unexpected and potent effect on weight loss, one important aspect of this class of drugs should not be overlooked: GLP-1 RAs have been shown to reduce the risk of heart attack, stroke, and other major adverse cardiovascular events (MACE) in patients with type 2 diabetes who have or are at high risk for atherosclerosis
Endothelial SIRT1 prevents age-induced impairment of vasodilator responses by enhancing the expression and activity of soluble guanylyl cyclase in smooth muscle cells
& Tan, N
Such observations could contribute to a deeper understanding of non-genetic regulatory mechanisms
Hypertension 60 , 757764 (2012)
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