Pharmacokinetics, pharmacodynamics, safety, and tolerability of a single-dose of NN2211, a long-acting glucagon-like peptide 1 derivative, in healthy male subjects
The mean concentrations of prolactin, TT, LH, and FSH were 8.8 ng/ml, 13.3 ng/dL, 7.2 IU/L, and 9.7 IU/L, respectively
These two mRNAs encode antizyme 1 isoform 1 (228 amino acids) and antizyme 1 isoform 2 (226 amino acids)
PMID: 25278298
This augmentation of insulinotropic polypeptide and glucagon secretion helps stabilize blood sugar
Conversely, satiety is primarily controlled by anorexigenic pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) neurons in the ARH that project to paraventricular nucleus neurons, resulting in the release -melanocyte-stimulating hormone and a decrease of food intake