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Although malonyl-CoA and long-chain acyl-CoA are believed to regulate GSIS, abrogation of malonyl-CoA formation by overproducing malonyl-CoA decarboxylase in beta cells did not interfere with GSIS, [58] whereas chronic, but not acute, suppression of ACC production by 6080% in INS-1 832/13 cells and isolated islets significantly reduced GSIS [59]

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Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications primarily used to manage type 2 diabetes mellitus and, more recently, for weight management in specific patient populations

Clinical trials for Zepbound showed that participants achieved an average weight loss of 15% to 22.5%, depending on dosage, with results tracked over 72 weeks under controlled conditions

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