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Even light to moderate exercise can make a meaningful difference
Specific Clinical Relevance Osteoarthritis GLP-1's primary advantage in OA is its dual capacity to modulate synovial macrophage polarization (M1M2) while directly inhibiting cartilage matrix-degrading enzymes (MMP-3, MMP-13, ADAMTS-4/5) and promoting COL2 and aggrecan synthesis
10.1177/1087057113499634 2 ApelK.HirtH
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331,332 Currently, a wide range of clinical trials are ongoing in which APR-246 administration has finished or has not yet been completed 12,333,334,335 (Table 3)
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