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Weight-related comorbidities include cardiovascular disease, prediabetes, type 2 diabetes, hypertension, and dyslipidemia
The honest framing: it is a low-risk adjunct layered on top of the things that actually drive results a calorie deficit, food quality, and physical activity
10.1038/s41586-019-1705-2 5 BhatM
Onset and adaptation: Appetite suppression effects appear within weeks, though side effects (nausea, fullness) may be stronger during dose escalation
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Since stimulants affect people differently, theres no specific recommendation for how much caffeine may be tolerable
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