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IGF-I receptor-induced cell-cell adhesion of MCF-7 breast cancer cells requires the expression of junction protein ZO-1

In these cells, a senolytic treatment significantly decreased the expression of senescence markers (p53, p21, and p16) and senescence-associated beta-galactosidase (SA--gal) activity, while increasing caspase-3 expression, indicative of enhanced apoptosis

Other times, depending on our lifestyle habits and exposures, we may produce so many free radicals that even eating a balanced diet may not be enough to counteract their damage

BMC Cancer (2014) 14:351

Many practitioners combine both routes for comprehensive coverage

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