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The nature of how impaired glutamate cysteine ligase, the enzyme that naturally produces gamma-glutamylcysteine (GGC), can make cells more susceptible to mutagens due to lower glutathione (GSH) [4, 5] has been well studied
Karim RZ, Li W, Sanki A, Colman MH, Yang YH, Thompson JF et al
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Before being discontinued, Lilly was running a Phase 1/2 study for LY3884963 in patients with frontotemporal dementia who harbor mutations to the progranulin gene, a key player in neuron survival
Early research suggests GLP-1 signaling may influence alcohol intake and other addictive behaviors, although most of this evidence is still preliminary and based on animal models or small human studies
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