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Collectively, GIP can act on the adipose tissue to increase adipose tissue blood flow, to enhance LPL-induced TAG clearance from the circulation and to stimulate adipocyte lipid storage

Warning: Risk of Thyroid C-Cell Tumors In studies with mice and rats, tirzepatide (the active ingredient in Zepbound and Mounjaro) caused thyroid tumors, including thyroid cancer

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GLP-1 medications have multiple different mechanisms in the body that help with diabetes and weight loss, including: Increasing the amount of insulin made by the pancreas , which helps control blood sugar in patients with diabetes Decreasing the amount of excess sugar made by the pancreas , which helps control blood sugar in patients with diabetes Slowing down digestion from the stomach , which results in feeling full for longer after eating Signaling to your brain that you are full after eating , which helps suppress appetite and control cravings Tirzepatide contains an extra mechanism of action that other GLP-1 medications do not, known as GIP (glucose-dependent insulinotropic polypeptide) agonism

Some patients use semaglutide for several months, while others continue longer to support ongoing weight management