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In less critical scenarios, the safest approach is to wait for data

Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence

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108, pp

This includes employing mitochondrial-targeted peptides and exploring gene therapies aimed at correcting defective mitophagy (e.g., via the PINK1-Parkin pathway) or normalizing imbalanced mitochondrial dynamics (Wang et al., 2025a

It is usually treated in the first instance with emollients, or creams containing vitamin D analogues (such as calcipotriol), vitamin A (retinoids) or corticosteroids