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Presented for research literature review only Joachim A et al

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Antioxid Redox Signal 22(9):744759 Nobrega-Pereira S, Fernandez-Marcos PJ, Brioche T, Gomez-Cabrera MC, Salvador-Pascual A, Flores JM et al (2016) G6PD protects from oxidative damage and improves healthspan in mice

The liver is the main site of ApoE synthesis and secretion, and the ApoE gene, especially the 4 allele, is the strongest genetic risk factor for sporadic AD, and some of the AD disease markers and therapeutic effects are even dependent on differences in ApoE genotype [82, 83]