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Thus, in ovarian cancer, CD163 is not strictly indicative of M2 polarization but is a marker of a more nuanced macrophage phenotype linked to disease progression and immune modulation (139)
The ESP-EORTC-EURACAN recommendations concerning Spitz melanoma should be applied also on the basis of the recent observation that a spitzoid morphology is not invariably associated with a Spitz genetic signature (14, 15)
2024 Jul 25;391(4):311-319
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