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That slow clearance is what makes splitting plausible: the drug hangs around long enough that smaller, more frequent injections can hold blood levels steadier
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However, avoid drinking large amounts of liquid with meals, as this can increase stomach volume and pressure
Other cellular mechanisms, which are not yet known, may contribute to the neuroprotective effect of this drug, or a longer treatment time to reverse this phenomenon may be necessary
However, in the presence of the phosphodiesterase III-inhibitor cilostamide, glucagon could increase FOC in HAP (Neumann et al
Lancet Neurol 19(7):582590
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