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It serves as a downstream mediator of GH signaling and has been extensively studied in muscle biology and metabolic research
MECHANISM CATEGORIES RESEARCH CONDITIONS SAFETY Side effects Hypoglycemia (binds insulin receptor at higher doses) Theoretical organ enlargement with chronic high-dose Theoretical concerns in active malignancy (IGF-1 axis) Known interactions Insulin / sulfonylureas (hypoglycemia risk) Concurrent rhGH not standard Contraindications Active malignancy (IGF-1 axis growth signaling) Pregnancy/lactation (unstudied) Diabetic retinopathy (theoretical exacerbation) REGULATORY STATUS FDA Not FDA-approved
Multiple studies show glutathione supplements help reduce neurotoxicity and neuropathy in cancer patients
Y.LeeK.-J
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Anim Reprod Sci 149:103116
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