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Tirzepatide did not demonstrate detectable attenuation of weight reduction-induced decreases in sleeping or 24-h energy expenditure, but there was a reduction in respiratory exchange ratio in the tirzepatide treatment arm compared with that in the placebo arm, consistent with an increase in fat oxidation
Results are not guaranteed and individual results vary significantly
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Heat dramatically increases the rate of hydrolysis
One key factor is metabolic adaptation
6 , 157170.e8 (2018)
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