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Thomson CD, Chisholm A, McLachlan SK, Campbell JM
Inflammation is widespread rather than localized to a single joint
For example, metformin, a well-studied HDT agent, not only limits excessive inflammation and tissue damage by modulating immune responses but also promotes autophagy through mTOR inhibition, thereby enhancing the clearance of M
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and (iso)citrate, m/z 459
Upon intravenous administration, nanoparticles are highly susceptible to protein corona formation, which can mask targeting ligands and trigger rapid opsonization (69, 70)
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