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Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

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Finally, the aggregation of SNAC in a membrane-like environment was also demonstrated using a detergent micelle model (CTAB), as evidenced by both DLS and NMR experiments (Fig

LRRK2 G2019S mutation exhibited increased LRRK2 activity, abnormal autophagy, and a decreased number of DA neurons, which were alleviated by the LRRK2 inhibitor PFE-360 (Zhang et al., 2017)