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2 Overview of osteoarthritis and ferroptosis 2.1 Pathogenic mechanisms of osteoarthritis OA is a common degenerative joint disease marked by gradual cartilage degradation, destruction of subchondral bone structure, synovial inflammation, and clinical symptoms such as joint pain

Glucose6-phosphate dehydrogenase deficiency is one of the most common enzyme defects in humans and it is highly prevalent among populations in malaria-endemic areas of sub-Saharan Africa and the Middle East where approximately up to 7.5% of people are affected (Nkhoma et al., 2009)

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