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However, their signaling diverges at later stages: in the tongue, activation of these receptors produces neurotransmission and conscious taste perception, whereas in the intestine, the same receptor types modulate hormone secretion (such as GLP-1 and GIP) through endocrine signaling pathways (48, 49)
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Remove any one of those factors and the medication's effectiveness drops significantly
Conclusion In summary, there is strong evidence from clinical trials for the use of GLP-1 RAs in the management of T2DM in people living with CKD
This suggests inhibition of vagal cholinergic input into the stomach with a concomitant increase in gastric volume, though the exact mechanism is not clear
