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Others struggle with the ongoing cost, insurance coverage, medication shortages, or the long-term commitment required to stay on treatment

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This selectivity was demonstrated in the landmark study by Raun et al.: at doses producing a maximum increase in GH, ipamorelin did not alter plasma cortisol or prolactin levels (Raun et al., Eur J Endocrinol 1998)

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Future research should focus on refining multimodal analgesia protocols and evaluating their effects on long-term outcomes