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The sections that follow apply this framework to specific physiological domains, beginning with metabolic and energy-balance peptides beyond the incretin family

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Insulin secretory granule biogenesis and the proinsulin-processing endopeptidases

In skin, GHK-Cu signals fibroblasts to produce collagen, modulates matrix metalloproteinases for balanced tissue remodeling, and triggers expression changes in approximately 31 percent of human genes toward a younger profile 1 9

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