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Renal diseases As previously reported, enhanced eryptosis contributes to the pathophysiology of several clinical disorders
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Pyroptosis is executed by the pore-forming protein GSDMD, which is always activated/cleaved by Caspase-1, murine Caspase-11 and its human orthologs Caspase-4 and Caspase-5, and Caspase-8 (Shi et al., 2017
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