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Insulin secretion and beta cell preservation Many in vitro and preclinical studies have examined agents that enhance insulin secretion, including agents that generate ATP, inhibit K + -ATP channels, raise cytosolic calcium, activate muscarinic or imidazoline receptors, suppress 2-adrenergic receptors, inhibit phosphodiesterases to increase cAMP, stimulate phospholipases or modulate various intracellular regulators of insulin exocytosis

However, no trial specifically studied the effects of routinely shortened intervals

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