TMPRSS2 is widely coexpressed in intestinal epithelial cells along with its signaling target protease-activated receptor 2 (PAR2)
According to FDA communications, the agency is not aware of a basis for compounding using those salts
These may include: Nausea, vomiting or diarrhoea (most common early on) Constipation Fatigue Mild increases in heart rate (similar to changes seen with GLP-1 medicines) Side effects were more frequent at higher doses (8 mg and 12 mg), but still rated mild to moderate overall
Direct glutathione supplementation: An RCT in India randomized 206 people with type 2 diabetes (aged 31-78, HbA1c 7.1-9.7%) to receive either 500 mg glutathione daily alongside antidiabetic medications for 6 months, or antidiabetic medications alone
In T2D patients, the effects were weaker, accounting for less than 13%
While many users experience mild to moderate issues, such as nausea, vomiting, and diarrhea, more serious health risks have been associated with the drug