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Unexplained increased appetite lasting more than one to two weeks, especially if accompanied by weight gain, may indicate inadequate dosing, medication tolerance, or an underlying medical condition requiring evaluation

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Incidence of any grade of retinopathy in individuals without diabetes-associated eye disease at baseline During the follow-up period, 128 of 1857 (6.9%) tirzepatide-exposed individuals with R0M0 at baseline, and 181 of 1946 (9.3%) unexposed individuals with R0M0 at baseline, developed new retinopathy R1M0 or above