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Erick Turner, who used to work for the FDA but is now at Oregon Health and Science University, said the fact many patients stopped suffering suicidal thoughts when they came off the drug made it 'harder to explain away the suicidality'
In particular, to recapitulate the proliferative phase, organoids are exposed to an estrogen receptor (ER) agonist (typically E2), while a combination of E2 with a progesterone receptor (PGR) agonist (typically P4 or medroxyprogesterone acetate (MPA)) and decidualization-promoting cyclic adenosine monophosphate (cAMP) is employed to replicate the transition to the secretory phase [53, 54, 63]
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