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1980 Dec 25;288(5792):715-7
Effects of IGF-1 isoforms on muscle-biology endpoints and sarcopenia [PMID: 30953403] Laboratory literature summary: Effects of IGF-1 isoforms on muscle-biology endpoints and sarcopenia
GLP-1 RAs reduced the composite outcome of all-cause mortality and HF hospitalization by 27% (HR 0.73
Most features of CKD-MBD are usually present by the time eGFR falls below 45 (stage 3b), though bone disease can begin as soon as stage 2 (eGFR 60 to 89)
A serious side effect (there currently isnt enough data available to know how often it occurs) is bowel obstruction
The positive news is that most side effects can be successfully managed
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