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Observational studies show that patients with diabetes taking tirzepatide were 60% less likely to be diagnosed with anxiety compared to non-users

Human relevance is uncertain GLP-1 receptors are expressed on rodent thyroid C-cells at higher density than in humans, and no causal relationship has been established in human epidemiological data

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Cardiovascular : Hypertension

GLP-1 Receptor Distribution: **Brain: Hypothalamus, brainstem (appetite, satiety, nausea signaling) GI tract: Slows gastric emptying Heart: Cardioprotective signaling (modest direct effects

2023;72(Suppl 1):456-P