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Glucose-dependent insulin-releasing polypeptide (GIP) and GLP-1 are both secreted in response to food ingestion and potentiate the glucose-induced insulin response (figure 1)
GLP-1 is naturally produced in the body and plays a crucial role in glucose control and insulin regulation
[5] [6] This means that whilst Wegovy can significantly reduce hunger and help control portion sizes, the foundation of successful weight loss remains a sustainable reduction in calorie intake combined with behavioural changes
Under MHRA 'borderline products' guidance, transdermal patches delivering active substances systemically would typically be classified as medicines requiring marketing authorisation
The initial VLEKT phase often results in pronounced weight loss due to reduced glycogen stores and accompanying water loss, which may serve as a psychological motivator, encouraging continued adherence to the dietary regimen [134]
