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One ligand interacts with the protein of interest (POI) while the other one recruits an E3 ubiquitin ligase, mostly CRBN (Cereblon) or VHL (Von Hippel-Lindau) 31,32
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The broader physiology of the role of growth hormone and IGF-1 in the body is why these protocols are guided by data rather than a fixed prescription
Timing matters: doses are typically separated from food (particularly carbohydrates and fats), because elevated blood glucose and somatostatin blunt the GH response
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