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Combination with Metformin or Metformin with Sulfonylurea In a 26-week, double-blind trial (Trial 3, NCT02607865), 1864 adult patients with type 2 mellitus diabetes on metformin alone or metformin with sulfonylurea were randomized to semaglutide tablets 3 mg, semaglutide tablets 7 mg, semaglutide tablets 14 mg orally once daily or sitagliptin 100 mg once daily

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However, the specific role of ferroptosis in this pathogenic cascade has been largely overlooked

doi: 10.1016/j.redox.2020.101544 123 NumakuraTSugiuraHAkaikeTIdaTFujiiSKoaraiAet al

PMID: 36932240