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The reality of oral administration for musculoskeletal indications is straightforward: the peptide disperses through the digestive system before it reaches the injury site, and what arrives at a tendon or joint after that journey is a fraction of what a subcutaneous injection placed near the tissue delivers

I've guided hundreds of patients through this process, and with the right technique, it can be quick and nearly painless

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What would move this position is: a randomised, placebo-controlled trial in a defined population with an objective primary endpoint, a pre-registered protocol, and pharmacovigilance over a clinically meaningful duration

Depending on the type of peptide, these injections can stimulate collagen production, enhance metabolism, or promote the release of growth hormones

This long half-life is what makes once-weekly dosing possible