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Pickart and Margolina (2018) review documents broad gene-expression effects in vitro

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Moreover, the shorter gene of DupA exerted some protective effect on the gastric mucosa and decreased the rate of gastric mucosal carcinogenesis in the later stages (Takahashi et al., 2013)

The long half-life is driven by albumin binding (greater than 99% bound), reduced DPP-4 degradation due to the Aib8 substitution, and slowed renal clearance of the larger albumin-bound complex