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Uncovering CNS access of lipidated exendin-4 analogues by quantitative whole-brain 3D light sheet imaging

Nausea, vomiting, diarrhea, and constipation affected 60 to 80% of participants at higher doses, though most symptoms were mild to moderate in severity

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Insulin resistance and hyperglycemia Long term use of IGF-1 LR3 may suppress growth hormone (GH) secretion through negative feedback, leading to decreased insulin sensitivity