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10.1016/j.phrs.2019.104554 32
As insulin resistance plays a role in the Alzheimer disease pathogenic pathway, GLP-1 receptor agonists can be used to increase neurogenesis and synaptic plasticity and decrease neuroinflammation and protein aggregations
Clinical GLP-1 medications such as semaglutide deliver hormone-level doses that activate GLP-1 receptors throughout the body, producing appetite suppression, delayed gastric emptying, and improved blood sugar control
For metabolism of NR, NRK1 is expressed in most tissues but is absent in the spleen and white adipose tissue, while NRK2 is only present in skeletal muscle, heart, and white adipose tissue (WAT) 40
Recent studies have raised concerns about a potential link between Ozempic (semaglutide) and serious vision problems, particularly the rare condition known as non-arteritic anterior ischemic optic neuropathy (NAION)
PubMed Jensen, L., Helleberg, H., Roffel, A., van Lier, J.J.,Bjrnsdottir, I., Pedersen, P.J., Rowe, E., Derving Karsbl, J., & Pedersen, M.L
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