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The absence of adverse events in short-term trials does not eliminate the need for monitoring when extending beyond 12 weeks

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J Mater Chem B (2014) 2(28):456471

Despite this promise, several critical limitations remain: No large-scale, randomized controlled human trials to confirm efficacy, safety, or long-term impact Toxicology and pharmacokinetic data are lacking, especially for chronic use or high-dose regimens Only one stereoisomer (all-L form) has been tested

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Although generally considered safe in research, reported side effects may include nausea, headaches, digestive issues, fatigue, appetite changes, fluid retention, dizziness, and fluctuations in blood sugar levels