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They are often multi-arm, dose-escalation trials designed to determine the appropriate therapeutic window in which optimal anti-tumour activity can be met, while reducing toxicity based on pharmacokinetics, bioavailability and patient compliance
Phase 3 results from the ATTAIN trials show meaningful weight loss
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doi: 10.1021/acscentsci.9b01063 106 SoulaMWeberRAZilkaOAlwaseemHLaKYenFet al
Cell Signaling Technology, Cat #2118)
