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It took more than two years of intensive, capital-intensive manufacturing expansion for both companies to resolve those shortages: tirzepatide was removed from the FDA shortage list on December 19, 2024, semaglutide on February 21, 2025

These two heart failure types have different causes and respond to treatment differently, with preserved ejection fraction, the most common type, not responding so well to traditional treatments, leading to considerable unmet clinical need

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