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Accutane (isotretinoin) can cause skin problems by reducing sebum (oil) production that leads to dryness, irritation, and increased sun sensitivity, and can also cause a temporary worsening of acne
The safety profile is excellent
It is chemically a true peptide (six amino acids, including two D-amino acid substitutions for stability), so unlike some non-peptide GH secretagogues it is correctly classified in this category
It can be, especially when tolerability, cost, or maintenance is the main issue
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