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In SURMOUNT-1, the most common adverse events at the 15 mg dose included nausea (31%), diarrhea (23%), constipation (11%), and vomiting (12%)
R.ZhangJ.et al
Arch Gynecol Obstet (2008) 277(6):53946
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In our in vitro assay, WWP-1, but not HECD-1, efficiently transferred ubiquitin molecules onto recombinant NHR-49, resulting in detectable polyubiquitinated species
In laboratory models, IGF-1 pathway stimulation increases expression of myogenic regulatory factors
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