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N.NovakB.CitronM.KaufmannS.RittgerA.et al
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In human cell culture studies, increased expressions of PAI-1 and VCAM-1 have been reported to be associated with hyperglycemia-related endothelial cell dysfunction, a process that predisposes vasculature to accelerated atherogenesis 52
Preclinical studies have established a causal link between the lack of sleep inhibition of immune surveillance and increased tumor growth in animal models
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This is called inflammation
Much of the subsequent work has instead concerned effects some distance from sleep, including opioid withdrawal models, stress and corticotropin responses, and antioxidant activity
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