Additionally, NAD + is required for fatty acid metabolism during -oxidation, glutaminolysis generating -ketoglutarate, mitochondrial shuttling of metabolites, and lactic acid fermentation 3,4,5
Statistical analyses Analyses were conducted using JMP16 for Windows
Methylation also contributes to DNA repair and genome stability, helping to protect cells from accumulated damage over time
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The metabolite of MPTP, MPP + , induces mitochondrial dysfunction, increases oxidative stress, and leads to neuronal death, exhibiting PD-like pathological characteristics 21
This supports the hypothesis that meningococcal translocation across brain barriers occurs primarily through the endothelium, without the active participation of immune cells