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The most widely reported clinical side-effect of GLP-1 therapy is nausea, which is seen in 1336% (lower incidence in once weekly preparations)

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Mechanism of action of RYBELSUS (semaglutide), the first FDA-approved semaglutide in a pill for adults with T2D 1 Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes